SCARRING ALOPECIA
Scarring alopecia
Also known as cicatricial alopecia, scarring
alopecia can affect Men and Women of all ages. The diagnosis of the
condition is possible in up to 3% of the patients. Though rare, some
examples of scarring alopecia are (to name a few):
The occurrence of scarring alopecia may point
to a bigger condition such as lupus erythematosus. This may even affect
some of the organs of the body. Where there are many types of scarring
alopecia, the condition commonly ends in irreversible follicular
destruction and permanent hair loss.
What are the causes of scarring alopecia?
Cicatricial alopecia is a very poorly
understood condition. Yet, all types of scarring alopecia display
inflammation of the hair follicle.
The most common cause of scarring alopecia is
attributed to the breakdown of the ‘master regulator’ called PPAR gamma
or peroxisome proliferator-activated receptor gamma. The primary
function of this regulator is the preservation of the hair follicles,
sebaceous glands, and stem cells. Research indicates that when the PPAR
gamma is decreased, then it leads to loss of sebaceous glands’
functions, which in turn results in the secretion of toxic lipids.
Inflammation is triggered due to its accumulation, which eventually
destroys the follicular activity.
Symptoms:
Though different types of scarring alopecia may
have slightly different symptoms, the most common ones noticed are
itching, pain, tenderness, burning, inflammation, and changes in the
appearance of the scalp. To diagnose cicatricial alopecia, it is
absolutely essential to conduct a clinical evaluation and in most cases,
a scalp biopsy may have to be obtained.
Treatment options include:
The treatment of scarring alopecia depends upon
the extent of the condition, its severity and particularly the cause.
Some treatment modalities are:
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